Significats de human melanocyte en anglès

Human melanocytes respond to several growth factors whose receptors have tyrosine kinase activity.

Inhibitory cytokines, especially transforming growth factor-beta, are important in homeostasis of normal human melanocytes.

Observations by TEM showed that madecassoside attenuated the damage of mitochondria in human melanocytes caused by oxidative stress.

Normal human melanocytes proliferate in vitro only in response to costimulation by at least two selected peptide growth factors.

Cultured normal human melanocytes were also susceptible to DA and thiol compounds were very efficiently protective against DA-induced cytotoxicity.

Conclusions: These results demonstrate the antioxidative effect of madecassoside on human melanocytes subjected to oxidative damage via the activation of autophagy.

Normal human melanocytes were separated from keratinocytes and maintained in culture using KGM medium supplemented with 12-O-tetradecanoylphorbol acetate and cholera toxin.

Whereas FES is highly expressed in normal human melanocytes, FES expression is strongly decreased in over 30% of human melanomas.

Survivin expression by western blotting was detected in four human metastatic malignant melanoma cell lines but not in cultured normal human melanocytes.